Cellular Biophysics of Innate Immunity
Imagine that you cut yourself and pathogens breach your skin barrier. This would trigger innate immune cells to rapidly move through-, deform in- and interact with cells in tissues to reach the pathogens and deploy various cell-scale mechanisms to neutralize them. Each step of this process requires immune cells to sense and respond to physical forces. Our lab aims to understand how innate immune cells detect, generate and transmit the cell-scale physical forces required for the well execution of their functions both in health and disease.